tectime

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  • tectime
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    My opinion, some peeps are ultrasensitive to low e2, but only a very small %%. Many times low e2 is confused with other conditions IMO[/QUOTE]

    ^^^^^^^yes indeed!^^^^^^

    tectime
    Member
    Quote Originally Posted by MR10X
    You wont crash your estrogen with an even higher dose of an AI,adex or aromasin arimidex – Anastrozole Type-II Aromatase Inhibitor Arimidex binds reversibly to the aromatase enzyme through competitive inhibition. This suppresses the conversion of androgens into estrogen. Circulating plasma estrogen can be reduced by nearly 85% in women using Arimidex. A common misconception is that aromatase inhibition is similar in men and women. However in trials when males were merQistered 1mg of Arimidex daily, circulating estrogen was only reduced by about 50%. Anastrozole is rapidly absorbed orally (time to reach maximum concentration, 1 hour) with a slow apparent clearance of 1.54 liters/h and a terminal half-life of 46.8 h. aromasin Study I: dose finding Two different doses of exemestane (Aromasin, 25-mg tablets) were merQistered orally in random order for 10 d with a 14-d washout in between. Twelve subjects were divided into 2 groups (treatment sequences): group I received 25 mg in period 1 and 50 mg in period 2, and group II received 50 mg in period 1 and 25 mg in period 2. Blood was withdrawn in the morning, between 0800-0900 h at the beginning of each treatment cycle and 24 h after the last dose of each treatment cycle (4 blood draws) for various pharmacodynamic assays. These included estradiol, estrone, estrone sulfate, androstenedione, testosterone, free testosterone, dehydroepiandrosterone sulfate, cortisol, SHRonin, IGF-I, IGF-binding protein-3, and plasma lipid profiles [triglycerides, total cholesterol, high density lipoprotein (HDL) cholesterol, and low density lipoprotein (LDL) cholesterol]. Safety data, including general chemistries, cell blood count (CBC), urinalysis, and liver profiles, were measured as well. All adverse events were recorded. Study I: dose finding Analysis of the data on hormone concentrations after the 25- and 50-mg doses showed no difference in any of the parameters measured due to an order effect; hence, the data were grouped for analysis by dose. The 25- and 50-mg doses of daily exemestane had comparable effects in suppressing circulating estrogen concentrations, with 38 ± 24% (mean ± sd; P = 0.002 vs. baseline) and 32 ± 29% (P = 0.008) decreases in estradiol concentrations, 71 ± 12% (P < 0.0001) and 74 ± 12% (P < 0.0001) decreases in estrone concentrations, and 45 ± 27% (P = 0.004) and 51 ± 20% (P = 0.02) decreases in estrone sulfate concentrations after doses of 25 and 50 mg, respectively. There was an increase in circulating testosterone concentrations after both 25 mg (60 ± 58%; P = 0.001) and 50 mg (56 ± 48%; P = 0.003) exemestane. Androstenedione concentrations were increased as well after 25 mg (32 ± 36%; P = 0.004) and 50 mg (47 ± 59%; P = 0.052) exemestane, respectively (Fig. 1 and Table 2). SHRonin concentrations were decreased by 21 ± 7% (P = 0.0003) and 19 ± 39% (P = 0.18) at 25 and 50 mg exemestane, respectively. Free testosterone concentrations were increased by 117 ± 74% (P = 0.0001) and 154 ± 95% (P < 0.0001) at both doses, due to the decrease in SHRonin and the increase in total testosterone. No effect on circulating dehydroepiandrosterone sulfate was observed at either dose. Serum cortisol concentrations increased significantly (38 ± 39%; P = 0.008) with the 25-mg dose, but not the 50-mg dose, yet the increase was well within the normal range of cortisol concentrations. Plasma IGF-I decreased significantly (-13 ± 11%; P = 0.008) after the 25-mg dose, but not the 50-mg dose. Similarly, IGF-binding protein-3 showed a trend toward lower concentrations after the 25-mg dose (-7 ± 13%; P = 0.09), but not the 50-mg dose. There were no changes in circulating serum triglycerides, cholesterol, or LDL or HDL cholesterol concentrations with either dose of exemestane. Table 2 summarizes the results of the hormonal and lipid data.

    Good job ! And right ! I’ve been telling people this for yrs. when on blasts I always take 1 mg daily pharma anastrozole. My bf% is low and I’ve yet to crash my estrogen. I do bloods every time and e2 has been as low as 8/9 and I’ve yet to feel any of the so called symptoms of low e. On 300 mg .5 mg anastrozole my Tes levels come back 2600 + and estro at 18.

    tectime
    Member
    250 mg wkly puts me at around 1800 serum tes levels and over 70 on free t. Hmm that’s enough to see some great gains. True I prefer 300+ mgs per wk even on cruise mode but with the proper food consumption and a good disciplined work out routine you can see gains and def maintain all gains from blast mode at 250 mgs/wkly. would i suggest such a low cycle dose…. No not unless it is accompanied by another compound, but anytime you can raise you tes levels to 3x your nat. you better see some gains of you need to get of your ass and get busy in the gym and kitchen!
    tectime
    Member
    Your crit will lower the minute you donate blood. How many points that will vary a double red will lower it more but donating alone will lower it enough. Your estrogen depends on many factors, but for one try to get bloods before you add an A.I. That way you can post results and someone can guide you on an amount to start on. You can start an a.i. but you won’t have a guide for later use.
    tectime
    Member
    Oh and OP I usually feel better within hrs of a blood let. By the time I eat a little oatmeal and hydrate up.
    tectime
    Member
    He said it affecting his cardio…. Not lethargic. High e2 doesn’t cause you to get winded early into your work out, it makes you not want to workout (*****fied). I’m sure his estrogen is def. high at that dose with no a.i. It’s gonna be high but the getting winded during workouts is a def. sign of high crit. Go get bloods go donate get an a.i. started and keep on rocking.
    tectime
    Member
    Sweet deca !

    tectime
    Member
    Sounds like your crit has gotten too high. You need to do bloods to see. Also go donate blood and see if that helps.
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