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Originally Posted by renepjd
I found this today as a news item. It looks interesting. It sort of fits in with this thread.
Interesting information about Danazol
A team of US and Brazilian researchers have used a synthetic sex hormone to stimulate production of a naturally occurring enzyme called telomerase that is capable of reversing ageing and has been dubbed a possible “cellular elixir of youth.”
While in embryos, telomerase is expressed by practically every cell. It can then only be produced in cells that are constantly dividing, such as blood-forming stem cells, which can differentiate into various specialized cells, scientists say. Certain cells avoid aging by using telomerase to lengthen their telomeres, which are DNA-protecting structures at the ends of chromosomes. The length of telomeres is a laboratory measure of a cell’s age, as each time a cell divides, its telomeres get shorter.
“In a healthy adult, telomere length varies from 7,000 to 9,000 base pairs on average. A normal person’s telomeres lose 50 to 60 base pairs per year, but a patient with telomerase deficiency can lose between 100 and 300 base pairs per year,” said Professor Rodrigo Calado, one of the scientists behind the research, the results of which were published in the New England Journal of Medicine.
Telomerase deficiency may cause some blood-related diseases, such as aplastic anemia. In the recent study, scientists treated 27 patients having telomere diseases with a steroid called danazol, a synthetic male hormone, leading to telomere elongation.
“In the patients who received danazol, telomere length increased by 386 base pairs on average over two years,” Calado said.
The research was based on previous findings that showed that androgens, which are converted into estrogens in humans, bind to female hormone receptors in the telomerase gene promoter region, stimulating expression of the enzyme in cells. The latest study “was designed to find out whether the effect we’d observed in the lab also occurred in humans, and the results indicate that it does,” the professor said.
While finding that sex hormones may be used to reverse one of the biological drivers of aging, researchers are cautious, as the risks of using the treatment in healthy people are not yet clear.
Originally Posted by InsaneMuscleYes, alas, I am on TRT. I’m doing well in the gym, and well in bed, at 75 fucking is very important to me. I refuse to grow old gracefully. I have a good body, still brown hair and lots of it and I can still attract the younger dark_sidecks and so far no complaints at all.
Originally Posted by InsaneMuscleYes, sorry for not updating. I went a bit overboard with the Arimidex , but I got it down – too far down. I started with 1 Arimidex EOD for a week. I dropped Testosterone to 100 mg per week.
Then I was taking
10,000 IU Vitamin D3 daily
1,000 IU Vitamin B6
1,000 IU Vitamin E
Multivit and Multi-Mineral and the Vitex (4 per night)I had new bloods and my Prolactin was OK, my DHT was OK, my SHRonin was a bit high, my estradiol was almost zero.
I started my 200 mg weekly testosterone once I got the bloods back and I added 50 mg Deca every week. It’s been 3 weeks now. My libido is going up and I’m feeling better. Erections are getting OK, but still a bit soft. Once I get more "in tune", I’m dropping the Deca and starting with the Aromasin .
From what I have read, 10 mg Aromasin EOD should be OK for my low T dosage, but once I feel good, I’ll get more bloodwork done until I get the right H10.
Gym work is getting back to normal. Weights aren’t feeling as heavy as they did. We do Flat Bench Mon, Incline Wed and Decline Fri. We do a warm-up set and then 4 sets of 3 reps followed by a 5th set of as many as possible. When we started this routine (and we do the same for Curls, and ALL barbell work) we started at 80% of our 1RM and then we add 2.5 kg every week.
When I was feeling bad my Bench dropped by almost 20 kgs, but I’m doing my 2.5kg per week extra so far and still managing to finish with 6 to 8 reps for the last set.
My wife never ceases to amaze me. Her legs are incredible. She did 480kgs (that’s 1058lbs)
and managed 5 reps on the incline leg press madark_sidene this morning and she’s 56. The other guy that trains with us is 42 and he lost it after 440 kgs. She doesn’t have the same kinda hormone problems we guys get and she takes NOTHING. She is contemplating trying some Anavar . I can’t see why, she can outlift just about every guy in the gym already on just about every exercise. Can you imagine a 5’4" woman 159lbs doing cable Bambssovers with 20 kg on each side? She does 10 reps without breaking a sweat.Sometimes I feel very inferior, but then, I’ll soon be 75 so I guess it’s not that bad and I’m very proud of her.
I’ll try to remember to update more often.
Originally Posted by Mr.BBI take 3 mg Melatonin every night, helps my sleep. I’ll try adding the zinc. I do have zinc tabs, I have mild BPH. When my e2 was up around 117, it was very difficult to urinate and I would have to go several times just to empty my bladder. Since I took the Arimidex , it has improved quite a bit. My sleep is also improving, but I’m still not right.
About 40% of my diet is carbs in the form of wholewheat bread, oats, sweet potato, broccoli etc, I eat a lot of peanut butter. I dropped my Testosterone to 100 mg per week. I have been lowering my calorie intake for about 6 weeks now. I had gained almost 3 cm around my waist. I’ve been eating around 300 cals per day less than my calculated amount. The 3 cm have gone!
Everything is more difficult when you reach 74!
Originally Posted by InsaneMuscleNo, I don’t take Vitamin C Supplement, maybe I should. I take 2,000 IU, vVitamin D3 daily, I take 100 mg B6. I take (now) VITEX 4 tabs every night, I take 1,000 IU Vitamin E. I also take a multi mineral tab daily.
I have a high protein diet (1.8 to 2.0 mg/kg), keep fats down to <30. Don’t drink, don’t smoke. Don’t eat candies, when I get back to normal, my main vice is sex. I LIKE sex, better than candy or beer!
I have a feeling that I’ve gone from too much e2 to too little. I guess I just have to wait until my doc gets back from his vacation in January.
Originally Posted by InsaneMuscleEven when my e2 was 117, I had no signs of gyro. I don’t remember ever crying in my life, let alone at watdark_sideng the Titanic go down, I usually find things like this hilarious. Emotions? What are they?
When I was 117 e2, I was having major problems sleeping, but I was falling asleep and feeling constantly tired during the day. My max lifts were still going up. I had no real problem getting an erection, but it was very flaccid. I had major problems trying to reach a climax, even masturbating.
After the Arimidex , it took just over a week before I started to be able to get a good nights rest. Erections are still flaccid, still problems readark_sideng a climax. Weights going DOWN. This morning 50 kgs on seated military press on the smith madark_sidene, felt like a ton. I only did 5 reps. Week before last, I did 10 reps at 75 kgs.
Originally Posted by Lee_1978Yes, but my question is, how does one definitively know what her your e2 is too high or two low.
Hunting around, I found an article which allegedly gives the symptoms of too high and too low e2. Sure they LOOKED different, but only because the word order and phraseology had been chanced for each.
The bottom line was that both sets of symptoms are more or less identical.
How can one say."My e2 is too high" or "My e2 Is too low"? Short of getting blood done every damn week or two.
Originally Posted by Mr.BBNo, I lost my libido, my erections, I was adark_sideng all over. My previous blood test showed that my estradiol was <0.1.
I stopped the testosterone completely for the three weeks I did the PCT, hoping that I could get my e2 back up and find out if I actually NEEDED to take an AI
I dropped my T from 200 to 125 weekly to see if such a small dose of testosterone as 125mg/week would need me to take an AI at all, because if you backtrack through threads, you will see that several have commented that maybe I don’t need to take any AI at all.
In the absence of a doctor with more than two grey cells to rub together, I have to look for advice from people who have been there and done it.
OK, maybe it wasn’t the right thing to do, but if I listened to my doctor(?) or endocrinologist(?), I would just lie down and die like a good elderly citizen should in these times of austerity and mass immigration.
You Originally Posted by InsaneMuscleIs this it? Vitex Agnus Castus: Vitamins & Supplements | eBay