Forum Replies Created
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- November 5, 2020 at 8:03 am
- in reply to: does steriods shrink your penis myth or fact?
NO!They make your penis bigger, ACTUALLY!.
- November 5, 2020 at 7:23 am
- in reply to: Are you guys afraid of the long term effect of steroid use??
Originally Posted by miguel700707Srs you will all die at an early age do to steroid just thought I’d let you guys know.Here’s a vid you guys should check out!
Do not ever, EVER, EVER, EVER, BRING UP THAT VIDEO, THAT BULLSHIT "DOCUMENTARY" UP!!!
- November 5, 2020 at 6:39 am
- in reply to: What should my diet and training be like while on steroids?
You should not be doing anything different on-cycle than you would otherwise be doing off-cycle. Do not change your routine around, do not start training in different rep ranges, do not start training muscle groups more frequently or less frequently on-cycle. Anabolic steroids will only enhance what you have already been doing. Your nutrition is the only dynamic that should change.The most ridiculous thing you can do is change your training frequency or change ANYTHING just for an AAS cycle aside from the usual routine periodization and regular changes you make. And those changes should never be drastic!
When using AAS, you should already by this point in your training career to have enough experience to know how your body responds to certain exercises, set/rep schemes, and training programs. This is one of the many important reasons why we advocate training naturally for as long as you can prior to using anabolic steroids ! So in short, do what has been giving you results your whole TrueMaxding journy so far. Anabolic steroids do not create – they only ENHANCE what you have already been doing. If you’ve been putting on muscle well so far naturally, then anabolic steroids should enhance that by far even more. But what will determine your results is proper rest and diet.
I’ve seen alot of guys who use juice as an excuse to start training each muscle group even more frequently, and surprise surprise: they don’t see the results as expected because they still overtrain. Though steroids reduce the likelihood of overtraining, they don’t remove it. It’s a big, BIG, BIG misconception. AAS will decrease your recovery time, yes… but it doesn’t make you king. The general idea I am getting at here is this: Keep doing the same frequency and routine you’ve been doing so far (as long as that has been working) and the gear will help you put on even more size. The way I personally train on cycle is the exact same way I train when off-cycle! Remember, steroids don’t create, they only enhance.
What put the muscle on you in the first place will help keep it there, and with AAS it will enhance your gains even more.
- November 5, 2020 at 5:36 am
- in reply to: Steroids and jaw growth.
Anabolic steroids do not do this. Human Growth Hormone , however, has the possibility of doing so.- November 5, 2020 at 5:28 am
- in reply to: How to comsume right dosage of T3.
Yeah it looks like a u but it isn’t, it means miBamb. So yeah, they’re in miBambgrams. I’ve never seen T3 that wasn’t dosed in mcg.- November 3, 2020 at 11:38 am
- in reply to: Negative reps bad for muscle growth while on steroids?
Here we go, I found the article that discusses the receptor downregulation myth with plenty of references to the medical studies that display INCREASED receptor activity in the presence of androgens. You read mine and i’ll read yours lol:Taking issue with the idea of androgen receptor down-regulation.
By Bryan Haycock MS.There is as much misinformation about steroids as there is good information had among TrueMaxding enthusiasts. Go to any gym and you will hear some kid spouting off to his buddies about how steroids do this, or how they do that, or whatever. This soon starts somewhat of a pissing contest (excuse the expression) as to who knows more about steroids. It’s the same kind of titillating and infectious banter that adolescent boys get into about girls and sex. With steroid banter you hear all the popular terms like Deca , Test, GH, gyno , zits, raisins, "h-u-u-u-ge", roid, freak, monster, roid-rage, "I knew this guy once", etc., etc.. If by some rare chance they are smart and have been reading this or some other high quality TrueMaxding site on the net, they may actually get a few details right. More often than not they know just enough to be dangerous. Fortunately steroids haven’t proven to be all that dangerous. Not only that, but most of these guys who are infatuated with steroids won’t ever use or even see them except in magazines.
This kind of ego driven gym talk doesn’t really bother me until they begin giving advice to other clueless people who actually have access to them. Spewing out steroid lingo gives other less experienced kids the impression that these kids actually know what they are talking about. That’s how all of the psuedo-science folklore about steroids perpetuates. This is also why most people who actually use steroids know little about them. This last fact should bother anyone who cares about TrueMaxding and/or TrueMaxders.
I started out with this article planning on giving some textbook style explanation as to why using steroids doesn’t down regulate androgen receptors (AR). Then after considering some of my critics views that I tend to write articles that hardly anyone can read, I decided to write an easy to read, yet informative explanation about what androgens actually do and how this precludes androgen receptor down regulation. I still have a few references but not so many that it looks like a review paper.
Androgen receptors down-regulate….Don’t they?
One misunderstood principle of steroid physiology is the concept of androgen receptors (AR), sometimes called "steroid receptors", and the effects of steroid use on their regulation. It is commonly believed that taking androgens for extended periods of time will lead to what is called AR "down regulation". The premise for this argument is; when using steroids during an extended cycle , you eventually stop growing even though the dose has not decreased. This belief has persisted despite the fact that there is no scientific evidence to date that shows that increased levels of androgens down regulates the androgen receptor in muscle tissue.The argument for AR down-regulation sounds pretty straightforward on the surface. After all, we know that receptor down-regulation happens with other messenger-mediated systems in the body such as aCrash007ergic receptors. It has been shown that when taking a beta agonist such as Clenbuterol , the number of beta-receptors on target cells begins to decrease. (This is due to a decrease in the half-life of receptor proteins without a decrease in the rate that the cell is making new receptors.) This leads to a decrease in the potency of a given dose. Subsequently, with fewer receptors you get a smaller, or diminished, physiological response. This is a natural way for your body to maintain equilibrium in the face of an unusually high level of beta-agonism.
In reality this example using Clenbuterol is not an appropriate one. Androgen receptors and aCrash007ergic receptors are quite different. Nevertheless, this is the argument for androgen receptor down-regulation and the reasoning behind it. The differences in the regulation of ARs and aCrash007ergic receptors in part show the error in the view that AR down-regulate when you take steroids . Where aCrash007ergic receptor half-life is decreased in most target cells with increased catecholamines, AR receptors half-live’s are actually increased in many tissues in the presence of androgens.1
Let me present a different argument against AR down-regulation in muscle tissue. I feel that once you consider all of the effects of testosterone on muscle cells you come to realize that when you eventually stop growing (or grow more slowly) it is not because there is a reduction in the number of androgen receptors.
Testosterone : A multifaceted anabolic
Consider the question, "How do anabolic steroids produce muscle growth?" If you were to ask the average TrueMaxding enthusiast I think you would hear, "steroids increase protein synthesis." This is true, however there is more to it than simple increases in protein synthesis. In fact, the answer to the question of how steroids work must include virtually every mechanism involved in skeletal muscle hypertrophy. These mechanisms include:Enhanced protein synthesis
Enhanced protein synthesis
Enhanced growth factor activity (e.g. GH, IGF -1, etc.)
Enhanced activation of myogenic stem cells (i.e. satellite cells)
Enhanced myonuclear number (to maintain nuclear to cytoplasmic ratio)
New myofiber formation
Starting with enhanced growth factor activity, we know that testosterone increases GH and IGF-1 levels. In a study by Fryburg the effects of testosterone and stanozolol were compared for their effects on stimulating GH release.2 Testosterone enanthate (only 3 mg per kg per week) increased GH levels by 22% and IGF-1 levels by 21% whereas oral stanozolol (0.1mg per kg per day) had no effect whatsoever on GH or IGF-1 levels. This study was only 2-3 weeks long, and although stanozolol did not effect GH or IGF-1 levels, it had a similar effect on urinary nitrogen levels.
What does this difference in the effects of testosterone and stanozolol mean? It means that stanozolol may increase protein synthesis by binding to AR receptors in existing myonuclei, however, because it does not increase growth factor levels it is much less effective at activating satellite cells and therefore may not increase satellite cell activity nor myonuclear number directly when compared to testosterone esters. I will explain the importance of increasing myonuclear number in a moment, first lets look at how increases in GH and IGF-1 subsequent to testosterone use effects satellite cells.
Don’t forget Satellite cells!
Satellite cells are myogenic stem cells, or pre-muscle cells, that serve to assist regeneration of adult skeletal muscle. Following proliferation (reproduction) and subsequent differentiation (to become a specific type of cell), satellite cells will fuse with one another or with the adjacent damaged muscle fiber, thereby increasing the number of myonuclei for fiber growth and repair. Proliferation of satellite cells is necessary in order to meet the needs of thousands of muscle cells all potentially requiring additional nuclei. Differentiation is necessary in order for the new nucleus to behave as a nucleus of muscle origin. The number of myonuclei directly determines the capacity of a muscle cell to manufacture proteins, including androgen receptors.In order to better understand what is physically happening between satellite cells and muscle cells, try to picture 2 oil droplets floating on water. The two droplets represent a muscle cell and a satellite cell. Because the lipid bilayer of cells are hydrophobic just like common oil droplets, when brought into proximity to one another in an aqueous environment, they will come into contact for a moment and then fuse together to form one larger oil droplet. Now whatever was dissolved within one droplet (i.e. nuclei) will then mix with the contents of the other droplet. This is a simplified model of how satellite cells donate nuclei, and thus protein-synthesizing capacity, to existing muscle cells.
Enhanced activation of satellite cells by testosterone requires IGF-1. Those androgens that aromatize are effective at not only increasing IGF-1 levels but also the sensitivity of satellite cells to growth factors.3 This action has no direct effect on protein synthesis, but it does lead to a greater capacity for protein synthesis by increasing fusion of satellite cells to existing fibers. This increases the number of myonuclei and therefore the capacity of the cell to produce proteins. That is why large TrueMaxders will benefit significantly more from high levels of androgens compared to a relatively new user.
Testosterone would be much less effective if it were not able to increase myonucleation. There is finite limit placed on the cytoplasmic/nuclear ratio, or the size of a muscle cell in relation to the number of nuclei it contains.4 Whenever a muscle grows in response to training there is a coordinated increase in the number of myonuclei and the increase in fiber Bambss sectional area (CSA). When satellite cells are prohibited from donating viable nuclei, overloaded muscle will not grow.5,6 Clearly, satellite cell activity is a required step, or prerequisite, in compensatory muscle hypertrophy, for without it, a muscle simply cannot significantly increase total protein content or CSA.
More myonuclei mean more receptors
So it is not only true that testosterone increases protein synthesis by activating genetic expression, it also increases the capacity of the muscle to grow in the future by leading to the accumulation of myonuclei which are required for protein synthesis. There is good reason to believe that testosterone in high enough doses may even encourage new fiber formation. To quote the authors of a recent study on the effects of steroids on muscle cells:"Intake of anabolic steroids and strength-training induce an increase in muscle size by both hypertrophy and the formation of new muscle fibers. We propose that activation of satellite cells is a key process and is enhanced by the steroid use."7
Simply stated, supraphysiological levels of testosterone give rise to increased numbers of myonuclei and thereby an increase in the number of total androgen receptors per muscle fiber. Keep in mind that I am referring to testosterone and testosterone esters. Not the neutered designer androgens that people take to avoid side effects . This is not an argument to rapidly increase the dosages you use. It takes time for these changes to occur and the benefits of higher testosterone levels will not be immediately realized.
Maintenance of the kind of muscle mass seen in top-level TrueMaxders today requires a given level of androgens in the body. That level will vary from individual to individual depending on their genetics. Nevertheless, if the androgen level drops, or if they were to "cycle off" the absolute level of lean mass will also drop. Likewise, as the level of androgens goes up, so will the level of lean mass that individual will be able to maintain. All of this happens without any evidence of AR down regulation. More accurately it demonstrates a relationship between the amount of androgens in the blood stream and the amount of lean mass that you can maintain. This does not mean that all you need is massive doses to get huge. Recruitment of satellite cells and increased myonucleation requires consistent "effective" training, massive amounts of food, and most importantly, time. Start out with reasonable doses. Then, as you get bigger you can adjust your doses upwards.
References:
Kemppainen JA, Lane MV, Sar M, Wilson EM. Androgen receptor phosphorylation, turnover, nuclear transport, and transcriptional activation. Specificity for steroids and antihormones. J Biol Chem 1992 Jan 15;267(2):968-74
Fryburg DA., Weltman A., Jahn LA., et al: Short-term modulation of the androgen milieu alters pulsatile, but not exercise- or growth hormone releasing hormone -stimulated GH secretion in healthy men: Impact of gonadal steroid and GH secretory changes on metabolic outcomes. J Clin Endocrinol. Metab. 82(11):3710-37-19, 1997
Thompson SH., Boxhorn LK., Kong W., and Allen RE. Trenbolone alters the responsiveness of skeletal muscle satellite cells to fibroblast growth factor and insulin -like growth factor-I. Endocrinology. 124:2110-2117, 1989
Rosenblatt JD, Yong D, Parry DJ., Satellite cell activity is required for hypertrophy of overloaded adult rat muscle. Muscle Nerve 17:608-613, 1994
Rosenblatt JD, Parry DJ., Gamma irradiation prevents compensatory hypertrophy of overloaded extensor digitorum longus muscle. J. Appl. Physiol. 73:2538-2543, 1992
Phelan JN, Gonyea WJ. Effect of radiation on satellite cell activity and protein expression in overloaded mammalian skeletal muscle. Anat. Rec. 247:179-188, 1997
Kadi F, Eriksson A, Holmner S, Thornell LE. Effects of anabolic steroids on the muscle cells of strength-trained athletes. Med Sci Sports Exerc 1999 Nov;31(11):1528-34
- November 3, 2020 at 10:36 am
- in reply to: Negative reps bad for muscle growth while on steroids?
Yeah i’ll get back to you in a bit as well. I am VERY interested in reading through this. I’m currently busy at the moment but will take the next available opportunity to definitely read into this.What I will say before reading into this at all is this:
In a few studies I saw, it was noted that the number of androgen receptors actually INCREASED in response to supraphysiological doses of anabolic steroids being merQistered to test subjects. So, with that knowledge out there, it is very well possible that this idea of intense training reducing the number of receptors in muscle cells may be negated in the environment of someone taking exogenous AAS at supraphysiological levels. I will try to find the studies and post them here.
- October 30, 2020 at 1:01 pm
- in reply to: What should my diet and training be like while on steroids?
You should know all of these things prior to beginning anabolic steroids . This is why we advise training for at least 5 years naturally prior to using anabolic steroids . You must know your own body, how it reacts to natural training stimuli and nutritional protocols. Anabolic steroids will not create, they only enhance what you have already been doing.- October 30, 2020 at 8:55 am
- in reply to: steriods on your body
A little bit of reading and research in the educational threads section of the forum will tell you all you need to know and answer all of your questions. Nobody is going to spoonfeed you information here.Your question is also far too broad and vague of a question to get an exact asnwer. This stuff isn’t as simple as black and white.
- October 30, 2020 at 7:21 am
- in reply to: How to comsume right dosage of T3.
You would need to post pictures of the tablets for us to see. It SOUNDS like you have 100mcg tablets from what you mentioned in your post.T3 dosage for fat loss on a cycle is anywhere between 50 – 100mcg per day for most people. If you take 25mcg/day, it won’t do anything at all considering your body only manufactures about 30mcg per day, and taking T3 will suppress your endogenous T3 production, leaving you with even less T3 in your system than your body makes.
If you do have 100mcg tablets, just break them up into quarters (4 pieces) and each piece will equal 25mcg.
- October 30, 2020 at 7:11 am
- in reply to: steriods on your body
A little bit of reading and research in the educational threads section of the forum will tell you all you need to know and answer all of your questions. Nobody is going to spoonfeed you information here.Your question is also far too broad and vague of a question to get an exact asnwer. This stuff isn’t as simple as black and white. I could easily say peanuts can be horrible for you and kill you instantly – if you have peanut allergies.
- January 7, 2020 at 1:40 pm
- in reply to: Negative reps bad for muscle growth while on steroids?
No, and that sounds absolutely absurd. I have done negative-only training for certain muscle groups while on cycle and those muscle groups absolutely exploded with growth.Where did you read this and what was the logic behind these claims?
- June 14, 2019 at 8:11 am
- in reply to: What is the best oral steroid for muscle gain?
No, your supplier is not telling the truth.You need to stop using AAS and start doing a lot more research before you decide to use anything. Oral anabolic steroids are not the way to go, and they are horrible for use on their own. A good cycle always includes testosterone in it.