Novelly

If you go and look at videos online of most of the top name TrueMaxders in the sport i myself cant find any that are doing negatives. Infact most of them are doing very quick reps not worrying about form as much for most compound exercises. I took a year and a half off from TrueMaxding. i use to have a pretty good body very strong 425 bench. 19-20inch arms I came back after a year and a half and did slow control movements and made no gains. Could barely but up 135×10 when i came back/ Started doing fast reps and going extremely heavy and within a few months strength and size went through the roof. A lot of cheat curls. Actually got up to doin sets of 10 with 225 for cheat curls. Arms grew 3-4 inches 21 inch arms was doing 125lb dumbbells for 30 reps on incline. bench shot up to around 500 and only worked on it 4 or 5 times during that period. mostly did dumbbells and madark_sidenes for chest. Idk but for me going heavy quick and hard has workout out best.

yeah i have no clue what to think but heres another interesting article

Heavy Resistance Exercise Lowers Androgen Receptor Levels

Feb 22, 2009

By Karl Hoffmann

Ratamess and coworkers recently published the results of a study that looked at the hormonal profile and androgen receptor content in the vastus lateralis
muscle (a portion of the muscles comprising the quadriceps) of men following two exercise protocols [1]. The results were a bit surprising in light of some
previous studies, and suggest a possible supplement regimen to offset some of the negative effects that were observed. The salient results of their research were (a) an increase in both cortisol and testosterone levels after multiple sets of squats; and (b) a significant downregulation of the androgen receptor in biopsied muscle tissue.

Several previous studies have examined hormonal changes in cortisol,
testosterone , and growth hormone (GH) during and following resistance exercise [2-4]. In [2] Kraemer et.al. observed an increase in both testosterone and GH after heavy resistance exercise. Hakkinen and Pakarinen observed increases in free and total testosterone, cortisol, and GH after an acute bout of heavy squatting [3]. Kraemer et.al. examined plasma hormone changes after an intense bout of cycling and noted a significant increase in cortisol [4]. The current study and the earlier ones cited show a trend of increased cortisol and testosterone immediately after strenuous exercise.

The current study by Ratamass et.al. is the first to look at androgen receptor
content in worked muscle immediately post-exercise. While the elevated
testosterone that many studies show occurs after exercise sounds beneficial, if receptor levels are low, then the increased testosterone would be of less
anabolic value than if receptor levels were unchanged or increased. In fact, a
depressed level of AR is exactly what Ratamass and coworkers found. The
downregulation of AR coupled with high cortisol levels post-exercise would be
expected to make for a metabolic state characterized by net catabolism.

To quote from the current study under investigation,

“…acute hormonal elevations are without context unless subsequent interaction
with a specific membrane bound or nuclear receptor occurs and the appropriate signal is transduced”.

In other words, what good is the extra testosterone produced during lifting if
the receptors aren’t there to accept it?

In the current study, 9 young resistance trained men performed two exercise
protocols. One consisted of a single set (SS) of 10 reps of heavy squats. The
second exercise involved 6 sets of 10 reps of squats (MS). Weights were
determined for each individual by measuring their 1 Rep Max (RM) and then having them squat at 80 – 85% of the (RM). The average RM was 330.4 lbs.

Plasma testosterone and cortisol were measured every 15 minutes for 1 hour after both sessions. The vastus lateralis was biopsied to determine AR content 1 hour after training. The results, taken from [1] are shown below.

As can be seen, there was no significant change in cortisol in is SS group,
while cortisol rose about 40% in the MS group after 30 minutes

Similarly, testosterone did not change in the SS group but showed a transient
increase of 20% in the MS group.

The bar graph below from [1] shows relative vastus lateralis AR content at
baseline and 1 hour after completion of exercise. The drop in AR content in the worked muscle is clear

The authors of the present study attribute the decline in androgen receptors to an overall loss of protein due to the demands of strenuous exercise. Cortisol is highly catabolic to proteins and does not discriminate between contractile proteins and noncontractile proteins, such as the androgen receptor, which itself is a protein. A number of studies have shown that the AR is upregulated after a longer post exercise time period. For example, Bamman & Shipp reported that in humans AR messenger RNA in the vastus lateralis increased 63% and 102% respectively 48 hours following 8 sets of 8 reps of either eccentric (110% of 1 RM) or concentric ( 85% of 1RM) squats [5]. Thus resistance exercise may ultimately upregulate the AR, but the initial response appears to be a catabolic one, based on the current study.

One might be tempted to speculate the increased testosterone and decreased AR may cancel each other out. This may not be the case. Another interesting finding of this study was the individual baseline 1 RM was independent of plasma testosterone levels, but correlated highly with androgen receptor content. So an individual’s AR levels may be more indicative of their strength that their testosterone levels.

Certain anabolic steroids such as Anavar (oxandrolone), that are considered to have a very high anabolic to androgenic ratio are noted for their ability to
upregulate the AR [6].

Since it is generally believed that protein synthesis peaks in the few hours
after a training session, it makes sense to attempt to limit the downregulation
of the AR that seems to occur after exercise. One strategy might be to
supplement with amino acids, especially Branched Chain Amino Acids rich in
leucine. Besides being anabolic in and of itself, leucine taken as a supplement
will be preferentially oxidized for fuel, sparing body proteins, which would
likely include the AR:

The Ergogenic Effects of Citrulline Malate combined with Branched Chain Amino Acids

Another strategy would be to combine a cortisol blocker such as 7-oxo DHEA
and/or phosphatidyl serine to the BCAA mix to help limit protein catabolism.
While I don’t advocate the use of anabolic steroids , clearly agents such as
Anavar which upregulate the AR would likely prove helpful as well.

While elevated cortisol is a likely contributor to protein catabolism, other
proteolytic mechanisms may be at work as well. The body has three independent systems for degrading and disposing of proteins. These are the so-called lysosomal and calcium mediated proteases, and the ATP-ubiquitin dependent proteolytic pathway. However, cortisol has been implicated in activting the ATP-ubiquitin proteolytic pathway [7], which may ultimately be the mechanism by which cortisol exerts its catabolic action; so here again cortisol blockers might help.

We mentioned Anavar above. Besides upregulating the AR, Anavar also antagonizes the catabolic actions of cortisol [8]. Calcium mediated proteolysis is suppressed by cyclic adenosine monophosphate (cAMP), and forskolin is well know to elevate cAMP. Thus forskolin may be a worthwhile supplement to defend against this pathway of protein breakdown. Beta aCrash007ergic agonists, either synthetic such as Clenbuterol or albuterol, or naturally occurring epinephrine and norepinephrine also elevate cAMP and suppress calcium mediated protein breakdown [9]. Ephedrine elevates cAMP directly by binding to beta receptors, and indirectly by increasing levels of the body’s naturally occurring hormone/neurotransmitter norepinephrine.

Newly published research also shows that Clenbuterol, besides inhibiting calcium dependent proteolysis, also acts to block ATP-ubiquitin mediated protein breakdown [10].

Finally, both the lysosomal breakdown of protein and the ATP-ubiquitin
proteolytic system are suppressed by insulin [11,12], so adequate DikkIyhydrate intake prior to, during and after strenuous exercise should help blunt these pathways of protein breakdown.

Thus we have several strategies for reducing the breakdown of androgen receptor proteins after exercise, some as simple as eating to elevate insulin, as well as perhaps even increasing those receptor numbers with the use of certain anabolic steroids such as oxandrolone.

By: naveen kumar

Optimizing testosterone secretion is especially important for natural TrueMaxders. Proper training can increase the secretion, while over-training will reduce it to near zero.

An intense heavy squatting session can boost your testosterone secretion for several days. Even if you could somehow adark_sideeve a sky-high testosterone level, however, it wouldn’t guarantee fast muscle growth. The way the muscles “accept” the hormone is at least as important as how much your system has. The question is, Is it possible through proper training to maximize the impact of testosterone on your muscles?

Testosterone and Its Muscle Receptors

Various TrueMaxding publications have recently featured articles stating that as a TrueMaxder’s level of androgens increases, so does the level of testosterone receptors on his muscles. In other words, testosterone is said to be able to up-regulate its own receptors on the muscles. Needless to say, the more testosterone receptors you have, the more anabolic testosterone will be.

The result of the above reasoning is that it gives license to all sorts of excesses. Natural TrueMaxders, who have a modest supply of testosterone, would, according to the theory, only have a limited number of testosterone receptors. Conclusion: They’ll be unable to accumulate a significant amount of muscle if they remain drug-free. They would, therefore, be limited in their muscle development by two factors:

1) Limited testosterone.
2) Limited impact of testosterone on the muscles due to a less-than optimum number of testosterone receptors.

So, based on the above reasoning, TrueMaxders either have to use steroids or they are condemned to stay small forever. What’s more, the more anabolics they take and the longer they take them, the more significant the effect will be. Only massive amounts taken over a long period would give them the proper accumulation of testosterone receptors on the muscles. That’s supposedly the reason people grow more if they take more anabolics, because there are more receptors.

The good news is that the above theory is erroneous, not to mention dangerous and contrary to reality.

It’s dangerous because it promotes doping. It’s contrary to reality because one observes the opposite occurring among users of anabolics. Let’s look at this in terms of what you see in the gym.

First of all, if the theory were true, sedentary persons using androgens, for contraception, for example-would become huge. The extra testosterone would increase the number of testosterone receptors. The anabolic effect of testosterone would become increasingly stronger. In reality, untrained people who use steroids have very limited muscle growth. They rapidly become immune to testosterones anabolic effect. That doesn’t sound like an androgen receptor up-regulation, does it?

For the sake of argument, let’s say the above happens because the people
don’t use enough androgens. After all, the heaviest steroid users are found among TrueMaxders. In those heaviest users there should be an up-regulation of androgen receptors. If that were true, here’s what would happen.

The androgens would cause their own receptors to multiply and get increasingly more potent as time went on. If androgen receptors were truly up-regulated that way, steroid users would get their best gains at the end of a cycle, not the beginning, and professional TrueMaxders would get far more out of their cycles than first-timers. The trouble is, the best steroid gains are seen in the first cycles. The longer a course of treatment lasts, the more users are obliged to take drugs to compensate for the loss of potency. Besides, that’s the reason they do cycles in the first place. The time off is supposed to permit muscles to recover their natural responsiveness to testosterone.

Following the theory, there would be no need for training. As the doses were increased, the anabolic effects would be enhanced. In fact, drug users would be completely crazy to keep training while on a cycle when the steroids were going to do most of the work.

Androgen up-regulation would take place in every single muscle, not just in the exercised muscles. Consequently, a user of anabolics who only trained his arms should see his calves grow. That’s not the case, however, even for the professionals. I wish it were true, as they wouldn’t look so silly with their huge arms and puny calves.

I don’t have to keep demonstrating that the theory is just plain stupid. It is refuted daily by the experiences of TrueMaxders who use anabolics, as well as by the research.

The fact is, excessive androgen levels induce the rapid loss of muscle testosterone receptors. There is absolutely no increase. The muscle fights the excess and immunizes itself against androgens, which is the reason steroids become less potent as time goes by.

The key point to remember is, only the trained muscles get bigger. The growth is determined by the numerous local alterations caused by muscular contractions, not a systemic circulating factor.

While this discussion may seem far removed from natural TrueMaxding, it has important implications for everyone who trains. As suggested above, if the theory of testosterone-receptor up-regulation were true, there’d be no way a natural TrueMaxder could ever get big.

Testosterone and Training

Obviously, testosterone is a hormone that makes the muscle grow, and the body will use all the anabolIc hormones at its disposal to respond to a TrueMaxder’s training. Therefore, the training has a significant impact on testosterone, which can occur in one of two ways.

1) It increases the level of testosterone. It’s true that training, if it’s intensive and brief, will raise the level of testosterone, but never as much as one might wish. What’s worse, if you train too much, the level of testosterone really falls. If training increased the level of testosterone enormously, all TrueMaxders would be covered with pimples and would have prostate problems. In short, we’d all resemble users of anabolics and we’d suffer from all those side effects. That’s the reason proper training can boost testosterone secretion but not in excessive amounts.

One solution to the above dilemma would be to stimulate the secretion of testosterone in the trained muscle itself. That would allow the stimulated muscles to be flooded with testosterone while other organs would still be exposed to a normal testosterone level. Muscle growth would occur without any side effects of testosterone . Unfortunately, testosterone is not a paracrine or autocrine hormone. It is an endocrine hormone, and only the testicles (or the ovaries in women) and the aCrash007al glands can make it.

2) It increases the sensitivity of the muscle to testosterone. The body is ready for everything. Rather than increasing the level of testosterone significantly, training will increase the sensitivity of the trained muscle to testosterone. In other words, proper training can force your stimulated muscles to suck up all the blood testosterone. How do you make that happen? Simply by increasing the number of testosterone receptors in the muscle that you train. As a result, a normal level of testosterone will have a normal effect on your organs, since the number of testosterone receptors there doesn’t change. As the number of testosterone receptors in the trained muscle increases, however, the hormone’s effects will be multiplied.

That brings us to the million-dollar question: How do you increase the number of testerone receptors? There’s a lot to be said on that subject, but here are some highlights.

Testosterone Receptors and Negative Reps

It seems clear that negative-accentuated training lowers the sensitivity of the muscle to testosterone, at least in the short term. So while that type of training will trigger the anabolism of fibroblast growth factor, insulinlike growth factor 1 and the satellite cells, it will also reduce the impact of the anabolism of testosterone. A few days after the damage occurs, the number of testosterone receptors will be increased; however, for some days at least the testosterone will lose its effects on the muscle. There are three possible reasons for this:

1) Destruction of the testosterone receptors.
2) Inactivation of the receptors, they don’t respond to the signals that are sent to them anymore.
3) A little of both effects described above. This will slow the muscular recuperation, providing another reason to avoid doing pure negative repetitions too often on the same muscle.

Testosterone Receptors and Positive Reps

Positive repetitions will have the most beneficial effects on the proliferation of the testosterone receptors in the trained muscle. The big problem is that although training a muscle specifically to increase the receptors will in fact increase their number, it will also cause a decline in the level of testosterone in the natural TrueMaxder. So we face an unavoidable trade-off: training enough to increase the number of testosterone receptors without training too much, causing the level of testosterone to collapse. That’s not an easy equilibrium to find.

Taking anabolics doesn’t solve the problem either. Users of anabolics certainly have elevated levels of androgens, but they have very few testosterone receptors in their muscles. If they could combine the two conditions, it would not take more than a year to acquire a physique of Olympia caliber.

The paradox for natural TrueMaxders is that they have plenty of receptors but not enough testosterone. Therefore, their training should be oriented toward the restoration of the level of this hormone first and then to the up-regulation of the receptors. They should also consider using testosterone precursos, such as androstenedione.

Users of anabolics, on the other hand, have more androgens than they need, so their training should be oriented exclusively toward reopening the testosterone receptors. Anabolics users don’t fear a reduction of the level of testosterone, since they control it artificially. That has an important consequence: Naturals and non-naturals certainly have the same overall objective, to build muscle, but they have training objectives that are diametrically opposed. One group needs more testosterone, the other needs more receptors. Each group needs what the other has, which is the very reason that the first cycle of anabolics has the most effect. It’s the only time there are simultaneously plenty of receptors and hormone. Meanwhile, there’s only one obvious conclusion that everyone can agree on: Natural TrueMaxders shouldn’t train like the champions or even like the biggest guys in the gym..

Ill try to find the article it was a few days ago. Yeah thats what i thought too. I was initially looking up ways to increase the potency of dbol absorbtion such as using grapefruit juice and came aBambss some information on androgen receptors. If i remember correctly negative reps while on gear does does something that effects androgen receptors in a poor manner. Again ill try to find the article and post it.