Dr.James

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  • Dr.James
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    Quote Originally Posted by MuscleScienceView
    I’m going to add my 2 cents.

    As Bizzaro points out it is tissue specific. In muscle tissue Tren will have a blocking effect for T on the AR due to its extremely highly binding affinity. Let’s just say for the sake of argument that you would have Free T floating around.

    My opinion on what I know and understand to be true of how androgens bind to the AR which remember is intra cellular and is not a second messenger like so many other cellular signaling pathways. This high affinity for binding would make anything other than a HRT level dosages a waste of compounds. On the flip side, if your goal was to "Saturate," the AR with T with extremely high dosages and playing on sheer probability of binding with higher numbers of molecules. Then what would be the point of then blocking Tren from binding to the AR with high Levels of T floating around?

    Wow…. you just spit some knowledge there!

    Dr.James
    Member
    Quote Originally Posted by marcusView
    I’m on week 4 of my test e cycle, pinning 250mg twice a week and just added anavar to the mix this week, 75mg a day. I’m on 0.25mg of arimidex eod and 250iu hcg twice a week. This is my second cycle.

    I’m on a cut cycle and feel the results aren’t really coming in as quickly as they did on my first cycle. I know it’s still early but thought I’d ask you guys what you think.

    If I don’t see results after xxx weeks would you suggest increasing my test e or anavar dose? And when increasing test/var doses do I also need to increase arimidex and hcg?

    Was your first cycle a bulk cycle? And this is a cut?

    Your dosage of Adex should be based on blood test results of your E2. HCG dosage is fine as is.
    If you don’t get results on Test E 500mg plus 75mg ED of var, then you bought fake stuff. Give it a little more time.

    How long was your last cycle and how long are you planning on running this cycle?

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